Altered pathogenicity in the liver induced by a mouse hepatitis virus type 3 thermosensitive mutant
Identifieur interne : 001425 ( Main/Exploration ); précédent : 001424; suivant : 001426Altered pathogenicity in the liver induced by a mouse hepatitis virus type 3 thermosensitive mutant
Auteurs : Jean-Pierre Martin [France] ; Annick Bingen [France] ; Françoise Koehren [France] ; Jean-Pierre Gut [France] ; André Kirn [France]Source :
- Journal of Hepatology [ 0168-8278 ] ; 1991.
English descriptors
- Teeft :
- Blood cells, Blot analysis, Body temperature, Electron microscope, Endothelial, Endothelial cell membranes, Endothelial cells, Fibrin deposits, Hepatitis, Hepatocytes, Important feature, Infection, Lesion, Lipid droplets, Liquid nitrogen, Morphometric study, Mouse, Mutant, Parenchymal cells, Persistent infection, Portal vein, Room temperature, Sinusoidal, Sinusoidal cells, Sinusoidal lesions, Small blocks, Viral, Viral antigens, Viral factors, Viral mrnas.
Abstract
Abstract: Intraperitoneal inoculation into sensitive BALB/c mice of D85, a thermosensitive (ts) mutant, provokes acute hepatitis followed by recovery of the mice. The ts mutant was able to replicate in the liver. However, the maximal viral titre was obtained 2 days later than was the case with the wild-type (wt) MHV 3 infection; the viral antigens remained localized within small foci and no invasion of the entire liver was observed. The hepatocytes infected with D85 showed strong steatosis similar to that induced by wt virus, but the other lesions induced by MHV 3 (closing of endothelial cell fenestrae and hepatocytolysis) were not seen. An important feature noticed with the D85 mutant concerned the establishment, in the surviving animals, of persistent infection: this phenomenon was demonstrated by the decrease of viral titre in the liver, viral RNA detection, and the fact that viral antigens gradually decreased until the 3rd month post-infection.
Url:
DOI: 10.1016/0168-8278(91)90865-9
Affiliations:
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mutant</title><author><name sortKey="Martin, Jean Pierre" sort="Martin, Jean Pierre" uniqKey="Martin J" first="Jean-Pierre" last="Martin">Jean-Pierre Martin</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Virologie de la Faculté de Médecine et Unité de Recherches, INSERM U74, Strasbourg</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Alsace (région administrative)</region><settlement type="city">Strasbourg</settlement></placeName></affiliation></author><author><name sortKey="Bingen, Annick" sort="Bingen, Annick" uniqKey="Bingen A" first="Annick" last="Bingen">Annick Bingen</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Virologie de la Faculté de Médecine et Unité de Recherches, INSERM U74, Strasbourg</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Alsace (région administrative)</region><settlement type="city">Strasbourg</settlement></placeName></affiliation></author><author><name sortKey="Koehren, Francoise" sort="Koehren, Francoise" uniqKey="Koehren F" first="Françoise" last="Koehren">Françoise Koehren</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Virologie de la Faculté de Médecine et Unité de Recherches, INSERM U74, Strasbourg</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Alsace (région administrative)</region><settlement type="city">Strasbourg</settlement></placeName></affiliation></author><author><name sortKey="Gut, Jean Pierre" sort="Gut, Jean Pierre" uniqKey="Gut J" first="Jean-Pierre" last="Gut">Jean-Pierre Gut</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Virologie de la Faculté de Médecine et Unité de Recherches, INSERM U74, Strasbourg</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Alsace (région administrative)</region><settlement type="city">Strasbourg</settlement></placeName></affiliation></author><author><name sortKey="Kirn, Andre" sort="Kirn, Andre" uniqKey="Kirn A" first="André" last="Kirn">André Kirn</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Virologie de la Faculté de Médecine et Unité de Recherches, INSERM U74, Strasbourg</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Alsace (région administrative)</region><settlement type="city">Strasbourg</settlement></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Hepatology</title><title level="j" type="abbrev">JHEPAT</title><idno type="ISSN">0168-8278</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1991">1991</date><biblScope unit="volume">13</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="61">61</biblScope><biblScope unit="page" to="70">70</biblScope></imprint><idno type="ISSN">0168-8278</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0168-8278</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Blood cells</term><term>Blot analysis</term><term>Body temperature</term><term>Electron microscope</term><term>Endothelial</term><term>Endothelial cell membranes</term><term>Endothelial cells</term><term>Fibrin deposits</term><term>Hepatitis</term><term>Hepatocytes</term><term>Important feature</term><term>Infection</term><term>Lesion</term><term>Lipid droplets</term><term>Liquid nitrogen</term><term>Morphometric study</term><term>Mouse</term><term>Mutant</term><term>Parenchymal cells</term><term>Persistent infection</term><term>Portal vein</term><term>Room temperature</term><term>Sinusoidal</term><term>Sinusoidal cells</term><term>Sinusoidal lesions</term><term>Small blocks</term><term>Viral</term><term>Viral antigens</term><term>Viral factors</term><term>Viral mrnas</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Intraperitoneal inoculation into sensitive BALB/c mice of D85, a thermosensitive (ts) mutant, provokes acute hepatitis followed by recovery of the mice. The ts mutant was able to replicate in the liver. However, the maximal viral titre was obtained 2 days later than was the case with the wild-type (wt) MHV 3 infection; the viral antigens remained localized within small foci and no invasion of the entire liver was observed. The hepatocytes infected with D85 showed strong steatosis similar to that induced by wt virus, but the other lesions induced by MHV 3 (closing of endothelial cell fenestrae and hepatocytolysis) were not seen. An important feature noticed with the D85 mutant concerned the establishment, in the surviving animals, of persistent infection: this phenomenon was demonstrated by the decrease of viral titre in the liver, viral RNA detection, and the fact that viral antigens gradually decreased until the 3rd month post-infection.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Alsace (région administrative)</li><li>Grand Est</li></region><settlement><li>Strasbourg</li></settlement></list><tree><country name="France"><region name="Grand Est"><name sortKey="Martin, Jean Pierre" sort="Martin, Jean Pierre" uniqKey="Martin J" first="Jean-Pierre" last="Martin">Jean-Pierre Martin</name></region><name sortKey="Bingen, Annick" sort="Bingen, Annick" uniqKey="Bingen A" first="Annick" last="Bingen">Annick Bingen</name><name sortKey="Gut, Jean Pierre" sort="Gut, Jean Pierre" uniqKey="Gut J" first="Jean-Pierre" last="Gut">Jean-Pierre Gut</name><name sortKey="Kirn, Andre" sort="Kirn, Andre" uniqKey="Kirn A" first="André" last="Kirn">André Kirn</name><name sortKey="Koehren, Francoise" sort="Koehren, Francoise" uniqKey="Koehren F" first="Françoise" last="Koehren">Françoise Koehren</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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